What is the treatment for amebiasis?

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If you are diagnosed with amebiasis, your doctor may prescribe Tindamax®, which is effective for treating the infection.

Simple dosing with high cure rates

Tindamax® dosing varies for adults and children according to the specific infection, but it is generally short in duration and very effective. For adults, the recommended treatment is one 2-gram dose a day for 3 days amebiasis, or 3-5 days for amebic liver abscess.

Figure 1 summarizes results from multiple studies on the efficacy of tinidazole in GI infections. The average cure rate in adults is 92% for intestinal amebiasis and 93% for amebic liver abscess.

Results of treatment studies for GI infections

Chart summarizing results from multiple studies on the efficacy of Tindamax<sup class='reg'>®</sup> in GI-related infections. Intestinal amebiasis cure rate among adults using 2 g QD for 3 days was 92%. Amebic liver abscess cure rate among adults using 2 g QD for 2 to 5 days was 93%.

† 8 randomized, comparative studies.1-7 Cure rates ranged from 80%-100%.

‡ 4 randomized, comparative studies.1,8-10 Cure rates ranged from 86%-93%.

§ 7 randomized, comparative studies;1,11-16 4 studies utilized at least 3 days of tinidazole. Cure rates ranged from 81%-100%.

Figure 1

  1. Bakshi JS, Ghiara JM, Nanivadekar AS. How does tinidazole compare with metronidazole? A summary report of Indian trials in amoebiasis and giardiasis. Drugs. 1978;15 Suppl 1:33-42.
  2. Jokipii L, Jokipii AM. Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects and drug absorption and elimination. J Infect Dis. 1979 Dec;140(6):984-8.
  3. Kyrönseppä H, Pettersson T. Treatment of giardiasis: relative efficacy of metronidazole as compared with tinidazole. Scand J Infect Dis. 1981;13(4):311-2.
  4. Gazder AJ, Banerjee M. Single-dose treatment of giardiasis in children: a comparison of tinidazole and metronidazole. Curr Med Res Opin. 1977;5(2):164-8.
  5. Nigam P, Kapoor KK, Kumar A, Sarkari NB, Gupta AK. Clinical profile of giardiasis and comparison of its therapeutic response to metronidazole and tinidazole. J Assoc Physicians India. 1991 Aug;39(8):613-5.
  6. Krishnamurthy KA, Saradhambal V. Single dose therapy of giardiasis: A comparative study of tinidazole and metronidazole in pediatric patients. Indian Pediatr. 1978 Jan;15(1):51-6.
  7. Speelman P. Single-dose tinidazole for the treatment of giardiasis. Antimicrob Agents Chemother. 1985 Feb;27(2):227-9.
  8. Swami B, Lavakusulu D, Devi CS. Tinidazole and metronidazole in the treatment of intestinal amebiasis. Cur Med Res Opin. 1977;5(2):152-6.
  9. Singh G, Kumar S. Short course of single daily dosage treatment with tinidazole and metronidazole in intestinal amebiasis: a comparative study. Cur Med Res Opin. 1977;5(2):157-60.
  10. Misra NP, Gupta RC. A comparison of short course single daily dosage therapy of tinidazole with metronidazole in intestinal amoebiasis. J Int Med Res. 1977;5(6):434-7.
  11. Kundu SC, Sen A, Bhattacherjee TD, Dasgupta DP, Majumdar S, Moorkerjee PK, Mukerjee AB. Comparative evaluation of tinidazole and metronidazole in the treatment of amoebic liver abscess. J Ind Med Assoc. 1977 Sep 16;69(6):127-9.
  12. Islam N, Hasan K. Tinidazole and metronidazole in hepatic amoebiasis. Drugs. 1978;15 Suppl 1:26-9.
  13. Khokhani RC, Garud AD, Deodhar KP, Sureka SB, Kulkarni M, Damle VB. Comparative study of tinidazole and metronidazole in amoebic liver abscess. Curr Med Res Opin. 1977;5(2):161-3.
  14. Mathur SN, Itigi A, Krishnaveni, Rai V. Tinidazole and metronidazole in the treatment of amoebic liver abscess. J Int Med Res. 1977;5(6):429-33.
  15. Simjee AE, Gathiram V, Jackson TF, Khan BF. A comparative trial of metronidazole v. tinidazole in the treatment of amoebic liver abscess. S Afr Med J. 1985 Dec 21;68(13):923-4.
  16. Mendis S, Dharmasena BD, Jayatissa SK. Comparison of tinidazole with metronidazole in the treatment of hepatic amoebiasis: a controlled double blind study. Ceylon Med J. 1984 Jun;29(2):97-100.

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