Tindamax (tinidazole) Efficacy and Dosing for Giardia, Amebiasis

Tindamax^® offers a potent, targeted therapy

Tinidazole is a widely used, highly effective treatment for giardiasis and amebiasis as well as amebic liver abscess, an extraintestinal infection caused by the same organism that causes amebiasis.

Giardiasis

Tinidazole (2-g single dose) use in giardiasis has been documented in 19 published reports from world literature involving both adult and pediatric patients.

In 8 controlled studies of 619 subjects, 229 were given a 2-g x 1-day (50 mg/kg x 1- day in pediatric patients) oral dose of tinidazole. Reported cure rates for tinidazole ranged from 80% (40/50) to 100% (15/15).
In 3 of the above trials, the 2-g/1-day dose of tinidazole was compared to 2- or 3-day regimens of varying doses of metronidazole. Reported cure rates for metronidazole ranged from 76% (19/25) to 93% (14/15). Data comparing a single 2-g dose of tinidazole to the commonly recommended 5-7 day dosing for metronidazole are limited.

Intestinal amebiasis

Tinidazole use in intestinal amebiasis has been documented in 26 published reports from world literature.

Most reports utilized tinidazole 2 g/day x 3 days.
In 3 of the above trials, the 2-g/1-day dose of tinidazole was compared to 2- or 3-day regimens of varying doses of metronidazole. Reported cure rates for metronidazole ranged from 76% (19/25) to 93% (14/15). Data comparing a single 2-g dose of tinidazole to the commonly recommended 5-7 day dosing for metronidazole are limited.

Amebic liver abscess

Tinidazole use in amebic liver abscess has been documented in 18 published reports from world literature involving over 470 patients.

Most reports utilized tinidazole 2 g/day x 2-5 days.
In 7 published, randomized, controlled studies (1 double-blind, 1 single-blind, 5 open-label) using the above dose accompanied by aspiration of the liver abscess when clinically necessary, reported cure rates among 133 subjects ranged from 81% (17/21) to 100% (16/16). Four of these studies utilized at least 3 days of tinidazole.

Tindamax^® dosing recommendations
for GI-related infections
	Adults	Children > 3 years of age
Giardiasis	2 g single dose	50 mg/kg single dose (up to 2 g)
Amebiasis	2 g QD × 3 days	50 mg/kg QD × 3 days (up to 2 g/day)
Amebic liver abscess	2 g QD × 3-5 days	50 mg/kg QD × 3–5 days (up to 2 g/day)

Cure rates with Tindamax^® in GI-related infections

Chart summarizing results from multiple studies on the efficacy of Tindamax<sup class='reg'>®</sup> in GI infections. Average giardiasis cure rate in children with a single 2 g dose was 90%. Intestinal amebiasis cure rate among adults using 2 g QD for 3 days was 92%. Amebic liver abscess cure rate among adults using 2 g QD for 2 to 5 days was 93%.

† 8 randomized, comparative studies.^1-7 Cure rates ranged from 80%-100%.

‡ 4 randomized, comparative studies.^1,8-10 Cure rates ranged from 86%-93%.

§ 7 randomized, comparative studies;^1,11-16 4 studies utilized at least 3 days of tinidazole. Cure rates ranged from 81%-100%.

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