It is advisable to take tinidazole with food to minimize the incidence of epigastric discomfort and other gastrointestinal side-effects. Food does not affect the oral bioavailability of tinidazole (see Clinical Pharmacology). Alcoholic beverages should be avoided when taking tinidazole and for 3 days afterwards (see Drug Interactions).
Bacterial vaginosis
The recommended dose in non-pregnant females is a 1 g oral dose once daily for 5 days taken with food or a 2 g oral dose once daily for 2 days taken with food. The use of tinidazole in pregnant patients has not been studied for bacterial vaginosis.
| 2 g/2-day dosing4 x 500 mg tablets once daily for 2 days, taken with food | 1 g/5-day dosing2 x 500 mg tablets once daily for 5 days, taken with food |
|---|---|
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| Table 1 | |
Trichomoniasis
The recommended dose in both females and males is a single 2 g oral dose taken with food. Since trichomoniasis is a sexually transmitted disease, sexual partners should be treated with the same dose and at the same time.
Giardiasis
The recommended dose in adults is a single 2 g dose taken with food. In pediatric patients older than three years of age, the recommended dose is a single dose of 50 mg/kg (up to 2 g) with food.
Amebiasis
Intestinal
The recommended dose in adults is a 2 g dose per day for 3 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3 days with food.
Amebic liver abscess
The recommended dose in adults is a 2 g dose per day for 3-5 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3-5 days with food. There are limited pediatric data on durations of therapy exceeding 3 days, although a small number of children were treated for 5 days without additional reported adverse reactions. Children should be closely monitored when treatment durations exceed 3 days.
| Indication | Adults | Children > 3 Years of Age |
|---|---|---|
| Trichomoniasis | 2 g single dose* | n/a |
| Giardiasis | 2 g single dose | 50 mg/kg single dose (up to 2 g) |
| Intestinal Amebiasis | 2 g QD × 3 days |
50 mg/kg QD × 3 days (up to 2 g/day) |
| Amebic Liver Abscess | 2 g QD × 3-5 days |
50 mg/kg QD × 3-5 days (up to 2 g/day) |
|
* Treat sexual partners with the same dose and at the same time. Please see full Prescribing Information. |
Table 2 | |
Compounding of the oral suspension
For those unable to swallow tablets, tinidazole tablets may be crushed in artificial cherry syrup to be taken with food.
Procedure for compounding of the oral suspension
Pulverize four 500 mg oral tablets with a mortar and pestle. Add approximately 10 mL of cherry syrup to the powder and mix until smooth. Transfer the suspension to a graduated amber container. Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a final volume of 30 mL. The suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature. When this suspension is used, it should be shaken well before each administration.
Health Professional Resources
Only Tindamax® is approved to treat both bacterial vaginosis and trichomoniasis (TV).
Clinical Insight
Oral vs vaginal cream therapy: Patient preference for oral dosing is demonstrated to be 84%. More»
Beyond BV
Tindamax® may be prescribed for other infections including:
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